AC-262,536

AC-262,536 Historical Development:

AC-262,536 was first synthesized by Acadia Pharmaceuticals, with the goal to explore its potential as a SARM. In the pursuit of developing therapeutically beneficial androgens that could promote muscle and bone growth without some of the unwanted side effects typically associated with androgenic steroids, AC-262,536 was discovered.

In preclinical studies, AC-262,536 demonstrated promising effects, showing anabolic properties in muscle and bone tissues with a reduced impact on prostate growth. However, it is important to note that AC-262,536 has not undergone clinical trials and remains a research chemical.

AC-262,536 Chemical Structure:

The chemical structure of AC-262,536 is characterized by the presence of a naphthalene ring, an uncommon feature among SARMs. The compound’s systematic name is N-(3-aminopropyl)-N-[2,3-dihydro-1H-inden-4-yl]-2,2-dimethylbutanamide. Here, the indene group attached to a dimethylbutanamide moiety imparts a unique structure-function relationship.

This unique architecture of AC-262,536 has been hypothesized to play a critical role in its selective androgen receptor activity, allowing it to elicit muscle and bone growth effects without triggering some of the common side effects seen with traditional androgens.

Properties and Mechanism of Action:

AC-262,536 operates by selectively binding to androgen receptors, promoting anabolic activity in muscle and bone tissues. In animal models, it was found to be about 66% as anabolic as testosterone but only about 27% as androgenic. This distinction makes AC-262,536 a particularly intriguing compound for those researching the potential of SARMs.

One notable property of AC-262,536 is its apparent neuroprotective effects. Studies have suggested it may counter the decline in cognitive function associated with aging, although these results are preliminary and need further investigation.

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