Buy Enclomiphene

Historical Development:

Enclomiphene’s journey began as a part of of clomiphene citrate, a drug synthesized in the late 1950s and later approved in the early 1960s. Clomiphene citrate is a mixture consisting of two isomers: enclomiphene and zuclomiphene.

In the early 2000s, researchers started to explore enclomiphene independently due to its favorable pharmacokinetic profile and estrogen receptor antagonism. The primary focus shifted towards the treatment of secondary hypogonadism in men, a condition characterized by low testosterone levels due to impaired signaling from the hypothalamus or pituitary gland.

Chemical Structure:

Enclomiphene, belongs to the class of compounds known as triphenylethylenes. Its chemical structure consists of a stilbene backbone with two phenyl rings and a central ethylene moiety, bearing a chlorine atom on one of the phenyl rings. Additionally, it possesses a phenoxy nitrogenous side chain with diethylamine at the terminal.

Properties and Mechanism of Action:

Enclomiphene is an estrogen receptor antagonist with selective estrogen receptor modulation (SERM) properties. Its antagonistic activity on the estrogen receptors, particularly in the hypothalamus, is central to its therapeutic efficacy. By blocking these receptors, enclomiphene inhibits the negative feedback of estrogen on the hypothalamic-pituitary axis, leading to an increase in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The rise in LH, in turn, stimulates the Leydig cells to produce more testosterone.

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