Ostarine MK-2866 Historical Development:
The genesis of MK-2866 can be traced back to the early 2000s. Developed by GTx, Inc., in conjunction with Merck & Co., the primary motivation behind MK-2866’s creation was to explore an alternative to conventional hormone replacement therapy (HRT) for conditions such as muscle wasting and osteoporosis. The overarching goal was to maximize the beneficial aspects of androgens on skeletal muscle and bone, while minimizing the impact on other tissues.
Ostarine MK-2866 Chemical Structure:
Chemically, MK-2866 is characterized by a central chiral carbon, attached to which are an aromatic phenoxy group, an amide functionality, and a 2-hydroxy-2-methylpropane moiety. This chiral center is of the S-configuration, which has been shown to be crucial for its biological activity.
Two cyano groups and a trifluoromethyl group adorn the molecule. These substitutions on the aromatic rings not only bolster the compound’s binding affinity for androgen receptors but also play an integral role in defining its selective nature. The hydroxyl group adjacent to the chiral center might also be implicated in forming critical hydrogen bonds with the androgen receptor, thus reinforcing MK-2866’s affinity and selectivity.
Properties and Mechanism of Action:
MK-2866 exhibits high selectivity for the androgen receptor in skeletal muscle and bone, while exerting less effects on the prostate and sebaceous glands. This is achieved through the unique chemical structure, which induces a particular conformational change in the androgen receptor, leading to the selective modulation of target genes.
Ostarine MK-2866 Half Life:
The half-life of MK-2866 is an important aspect of its pharmacokinetics. At roughly 24 hours, most clinical studies have used once a day dosing protocols.
We also offer this product in powder form. You can purchase 1000mg here: MK-2866 Powder
All of our products, including MK-2866 are third party tested to ensure we’re only supplying the highest quality compounds available. Feel free to call or email the lab on our COAs to ensure that when you buy SARMs, you’re getting exactly what you want when you place an order.
|Also Known As
|Ostarine, Enobosarm, GTx-024
|Store in a cool dry place
|The products we offer are intended for laboratory research use only.
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