Discovering RAD140:

RAD140, widely known as Testolone, was discovered by Radius Health, a pharmaceutical company that filed a patent for it in 2007. They designed RAD140 with a clear goal: to capture the power of androgenic activity for skeletal muscle and bone, while cutting back on the unwanted side effects common with traditional androgens. As a potent SARM, RAD140 showed potential as a therapeutic agent in combating muscle wasting diseases, osteoporosis, and other conditions.

The Unique Chemical Structure of Testolone:

Unlike typical SARMs, RAD140 boasts a distinct and intricate chemical structure. It stands out with its exclusive bicyclic core structure, combining a benzonitrile and a 1,3,4-oxadiazole ring. These rings bond through a cyanophenyl group, creating a structure that harmonizes perfectly with the androgen receptor.

On top of that, RAD140 exhibits a chloro-substituted phenyl group, a cyano group, and a hydroxy group within its structure. These vital functional groups enhance its binding capacity to the androgen receptor, likely holding the keys to its selective androgen receptor modulating activity.

Mechanism of Action:

RAD140 operates with laser-like focus, zoning in on androgen receptors in skeletal muscle and bone tissue to deliver its anabolic effects. It works by attaching onto the androgen receptor, triggering a conformational shift that paves the way for selective gene transcription.

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