S-4 Andarine Historical Development:
The inception of Andarine can be traced back to the late 20th and early 21st century, when it was developed by GTX, Inc., a pharmaceutical company with an affinity for developing treatments for conditions like muscle wasting and osteoporosis. Andarine emerged as one of the pioneering molecules in the SARM category. The compound was designed to selectively bind to androgen receptors, aiming to spur anabolic activity in bone and muscle tissues while steering clear of undesirable androgenic side effects.
S-4 Andarine Chemical Structure:
Chemically, Andarine is denoted as (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propanamide. The molecular structure is comprised of an acetamidophenoxy group, a hydroxymethyl group, and a nitrotrifluoromethylphenyl group, combined in a unique configuration. This architecture is vital as it imparts selectivity and affinity for androgen receptors, distinct from conventional, less selective structures.
S-4 Andarine Properties and Mechanism of Action:
Andarine exhibits a high degree of affinity and selectivity for the androgen receptor. Its mode of action is attributed to its capacity to act as a partial agonist of the androgen receptor. When bound to the receptor, it selectively promotes anabolic processes in skeletal muscle and bone tissue. However, in tissues where androgenic effects are generally unwarranted, such as the prostate and sebaceous glands, it displays markedly diminished agonistic activity, thus potentially reducing the propensity for androgenic side effects.
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