Buy Liquid RU-58841

RU-58841 Historical Development:

The history of RU-58841 can be traced back to the early 1990s. Scientists initially synthesized and developed it at Roussel Uclaf, a French pharmaceutical company. The research was directed towards finding novel antiandrogen compounds that could be effective in conditions triggered by the actions of dihydrotestosterone (DHT) – a potent androgen. One particular area of interest was androgenetic alopecia, a condition characterized by progressive hair loss due to the sensitivity of hair follicles to DHT. RU-58841 emerged as a potential candidate, demonstrating topical efficacy in inhibiting DHT’s action on hair follicles.

RU-58841 Chemical Structure:

Chemically, RU-58841 is comprised of a dichloro-flutamide backbone, which is similar to that of established antiandrogen drugs. The molecular structure is characterized by an aromatic ketone moiety linked to a thiohydantoin group through an amine linker. The compound also features two chlorine atoms attached to the phenyl ring, and a cyclohexylmethyl group attached to the thiohydantoin moiety.

RU-58841’s structure is specifically designed to provide it with a high affinity for binding to androgen receptors. The chlorine substituents and the cyclohexylmethyl group are believed to play a pivotal role in enhancing the compound’s binding affinity and selectivity for androgen receptors.

Properties and Mechanism of Action:

RU-58841 exhibits potent antiandrogenic activity. It operates by competing with DHT for binding sites on androgen receptors in the hair follicles. By binding to these receptors, RU-58841 prevents DHT from exerting its effects, which includes the miniaturization of hair follicles that leads to hair loss.

One of the distinguishing properties of RU-58841 is its localized action. When applied topically, the compound is thought to act on the hair follicles without significant systemic absorption. This localized action should help minimize potential systemic side effects that are associated with orally administered antiandrogens.