In the early 2000s, the idea behind MK-2866, also know as Ostarine, sprouted in the minds of researchers at GTx, Inc. Teaming up with Merck & Co., they aimed to craft an innovative alternative to conditions such as muscle wasting and osteoporosis. Their goal was to tap into the potential of androgens to bolster skeletal muscle and bone health, all while keeping the effects on other tissues to a bare minimum.

MK-2866 is chemically intriguing, with its chiral carbon core, surrounded by an aromatic phenoxy group, an amide functionality, and a 2-hydroxy-2-methylpropane unit. The key to its biological activity lies in the S-configuration of this chiral center.

The molecule flaunts two cyano groups and a trifluoromethyl group, like jewelry adorning an intricate structure. These additions to the aromatic rings don’t just boost the compound’s affinity for androgen receptors. They are crucial players in determining MK-2866’s selective nature. Another interesting aspect of it’s structure is the hydroxyl group, tucked beside the chiral center, which may play a pivotal role in strengthening MK-2866’s selectivity and affinity.

MK-2866 shows a marked preference for the androgen receptor in skeletal muscle and bone. At the same time, it treads lightly on the prostate and sebaceous glands. This balancing act stems from its unique chemical structure. It induces a distinct conformational shift in the androgen receptor, selectively tweaking the modulation of target genes.

The half-life of MK-2866 is an important aspect of its pharmacokinetics. At roughly 24 hours, most clinical studies have used once a day dosing protocols.

To help convert MK-2866 powder into a liquid version, we also offer PEG 400.

All of our products, including MK-2866 are third party tested to ensure we’re only supplying the highest quality compounds available. Feel free to call or email the lab on our COAs to ensure that when you buy SARMs, you’re getting exactly what you want when you place an order.

The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.