RAD 140 SARM:

Historical Development of RAD 140 – Testolone:

The birth of RAD 140, also known as Testolone, traces back to the early 21st century. It was first described in a patent filed by the pharmaceutical company Radius Health in 2007. The intention behind RAD140’s creation was to harness the benefits of androgenic activity, specifically on skeletal muscle and bone, while minimizing undesirable side effects associated with traditional androgens. Conditions such as muscle wasting diseases, osteoporosis, and certain forms of breast cancer were seen as potential therapeutic targets for this novel SARM.

RAD 140 Chemical Structure:

RAD140’s chemical structure is unique and complex. It features a distinctive bicyclic core structure comprising a benzonitrile and a 1,3,4-oxadiazole ring. These two rings are linked by a cyanophenyl group, creating a structure that interacts favorably with the androgen receptor.

RAD140 also features a chloro-substituted phenyl group, a cyano group, and a hydroxy group within its structure. These functional groups contribute to its high binding affinity for the androgen receptor and are thought to play key roles in its selective androgen receptor modulating activity.

RAD 140 Properties and Mechanism of Action:

RAD140 selectively targets androgen receptors in skeletal muscle and bone tissue, to exert it’s anabolic effects. It functions by binding to the androgen receptor and inducing a conformational change that allows for selective gene transcription.

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